Bioorganic and Medicinal Chemistry Letters p. 2823 - 2826 (1996)
Update date:2022-08-03
Topics:
Wang, Binghe
Wang, Wei
Zhang, Huijuan
Shan, Daxian
Smith, Terrill D.
A coumarin-based esterase-sensitive cyclic prodrug of an opioid peptide, DADLE, was prepared. The cyclic prodrug quickly released (t( 1/4 ) = 761 min) its original peptide, DADLE, upon esterase catalyzed hydrolysis. Such a system can be used for the preparation of cyclic prodrugs of other biologically active peptides aimed at improving their bioavailability.
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