Bioorganic and Medicinal Chemistry Letters p. 1121 - 1126 (1999)
Update date:2022-08-05
Topics:
Hu, Lain-Yen
Ryder, Todd R.
Nikam, Sham S.
Millerman, Elizabeth
Szoke, Balazs G.
Rafferty, Michael F.
Selective N-type Voltage Activated Calcium Channel (VACC) blockers have shown utility in several models of stroke and pain. In the process of searching for small molecules as N-type calcium channel blockers, we have identified a series of N,N-dialkylpeptidylamines (e.g., PD 175069) with potent functional activity at N-type VACC. Further modification of the leucine moiety of PD 175069 with a cyclized ring structure provides a series of novel molecules. Syntheses and pharmacological evaluation of the series are presented.
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Doi:10.1002/ejoc.201200727
(2012)Doi:10.1038/206830b0
(1965)Doi:10.1021/jf990132f
(1999)Doi:10.1016/S0022-328X(99)00214-4
(1999)Doi:10.1016/S0022-328X(99)00096-0
(1999)Doi:10.1002/ejoc.200200593
(2003)