Bioorganic and Medicinal Chemistry Letters p. 3127 - 3132 (1999)
Update date:2022-08-04
Topics:
Koshida, Shuhei
Suda, Yasuo
Sobel, Michael
Ormsby, Julie
Kusumoto, Shoichi
A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [3H]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-D-glucopyranosyl)- (1→4)-O-(2-O-sulfo-α-L-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets.
View MoreXuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Hangzhou Bayee Chemical Co.,Ltd.
Contact:+86-571-86990109
Address:No.380, Jiangnan Auenue, Binjiang District, Hangzhou, China
Contact:+86-533-3112891
Address:zibo
Beijing Huikang Boyuan Chemical Tech Co.,LTD
Contact:+86-10-68862197
Address:No.7 Haiying Road,Science City,Fengtai District,Beijing,China
Shanghai Witshoot Internet Technology Co Ltd
Contact:+86-21-66390020
Address:Room 419, No.285 Luochuan Road (E)
Doi:10.1039/P29860001211
(1986)Doi:10.1016/j.bmcl.2016.09.050
(2016)Doi:10.1016/0022-328X(86)80149-8
(1986)Doi:10.1021/jo801544w
(2008)Doi:10.1021/ol801671w
(2008)Doi:10.1002/chem.200701868
(2008)