Journal of labelled compounds and radiopharmaceuticals p. 261 - 270 (2000)
Update date:2022-08-02
Topics:
Chen, Bang-Chi
Sundeen, Joseph E.
Guo, Peng
Bednarz, Mark S.
Hangeland, Jon J.
Ahmed, Syed Z.
Jemal, Mohammed
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
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