Phytochemistry p. 4337 - 4342 (1992)
Update date:2022-08-03
Topics:
Ori, Kazotomo
Mimaki, Yoshihiro
Sashida, Yutaka
Nikaido, Tamotsu
Ohmoto, Taichi
The methanolic extract of the fresh bulbs of Fritillaria persica has yielded five new steroidal alkaloids.Their structures have been shown by spectral analysis and chemical evidence to be (25R)-22,26-epimino-3β-hydroxy-5α-cholest-22(N)-en-6-one 3-O-β-D-glucopyranoside; (25R)-23,26-epimino-3β-hydroxy-5α-cholest-23(N)-ene-6,22-dione and its 3-O-glucoside, and their C-20 epimers.The inhibitory activity of the alkaloids on cyclic AMP phosphodiesterase was examined. Key Word Index: Fritillaria persica; Liliaceae; bulbs; steroidal alkaloids; cyclic AMP phosphodiesterase; inhibitory activity.
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