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with satisfactory yields make them very promising catalyst. Fur-
ther, a key advantage of this ligand and complex over some others
is that the reactions can typically be performed in standard labora-
tory glassware without dry-box technique. Though a variety of
palladium complexes have been employed as efficient catalysts
for the Buchwald–Hartwig amination reaction, the use of palla-
dium(II) thiosemicarbazone complex as catalysts for this reaction
has not been explored earlier.
In conclusion, mononuclear palladium(II) thiosemicarbazone
complex has been synthesized and characterized by analytical
and spectral methods. X-ray diffraction study of the complex
confirms the N and S coordination mode of the ligand and reveals
the presence of a distorted square planar geometry around the
Pd(II) ion. The utility of the new complex as excellent pre-catalysts
for the Buchwald–Hartwig amination reaction has been high-
lighted by the coupling reaction of activating, neutral and deacti-
vating aryl- and heteroaryl bromides or dibromides with
secondary amines. The complex also acts as efficient catalyst for
the Buchwald–Hartwig amination reaction of difficult substrates
such as aryl- or heteroaryl chlorides with secondary amines.
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We sincerely thank the Council of Scientific and Industrial
Research (CSIR), New Delhi, India, for financial support [09/
475(0140)2008-EMR–I] and for Senior Research Fellowship to
R.N.P. We express sincere thanks to DST-FIST, India for the use of
Bruker 400 MHz spectrometer at the School of Chemistry,
Bharathidasan University, Tiruchirappalli.
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Supplementary data
Crystallographic data for the structural analysis have been
deposited with Cambridge crystallographic center, CCDC No.
882239. Copies of this information may be obtained free of charge
from The Director, CCDC, 12 Union roads, Cambridge CB2 1EZ, UK
(email: deposit@ccdc.cam.ac.uk). The summary of the data collec-
tion and refinement parameters for the complex; Experimental
procedures; 1H, 13C and 31P NMR spectra of the complex; 1H
NMR data for all the Buchwald–Hartwig coupling products.
Supplementary data associated with this article can be found, in
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