Bioorganic and Medicinal Chemistry Letters p. 1241 - 1244 (2000)
Update date:2022-08-05
Topics:
Gasparini, Fabrizio
Inderbitzin, Werner
Francotte, Eric
Lecis, Gabrielle
Richert, Paul
Dragic, Zorica
Kuhn, Rainer
Flor, Peter J.
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.
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