Tetrahedron Letters p. 4363 - 4366 (2000)
Update date:2022-08-04
Topics:
Collot, Valérie
Varlet, Didier
Rault, Sylvain
In order to design 2-azabioisosteres of tryptamine, serotonin or melatonin, the conditions of the Heck coupling reaction of 3-iodoindazoles with methyl acrylate are studied. This reaction authorizes the synthesis of 3-indazolylpropenoates as key intermediates to prepare 3-indazolylpropionic acids and 3-indazolylethylamines. The flexible synthetic strategy allows molecular diversity. (C) 2000 Elsevier Science Ltd.
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(2000)