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at 100 °C for 10 h. After cooling to room temperature, the reaction
mixture was extracted with ethyl acetate (15 mL), and the organic
layer was washed with water (3ϫ 15 mL). After drying with
Na2SO4, the combined ethyl acetate extracts were concentrated
in vacuo, and the residue was purified by flash column chromatog-
raphy on silica gel to give the product.
Supporting Information (see footnote on the first page of this arti-
cle): Experimental details, characterization data, and copies of the
1H and 13C NMR spectra of all key intermediates and final prod-
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Acknowledgments
This work was financially supported by the National Program on
Key Basic Research Project of China (973 Program,
2013CB328900) and the National Natural Science Foundation of
China (Grant No. 21202107 and 21021001).
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Received: July 24, 2013
Published Online: October 2, 2013
Eur. J. Org. Chem. 2013, 7050–7053
© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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