Archiv der Pharmazie p. 429 - 436 (1993)
Update date:2022-08-03
Topics:
Schlichter
Frahm
Asymmetric synthesis of trans- and cis-2-Benzamido- or 2-Phenyl-acetamido-cyclohexane-amines 7 and 8 by means of reductive amination and hydrogenolysis is described. Condensation of the amido-ketones 3 with chiral auxiliary (R)-(+) and (S)-(-)-1-phenylethylamine, respectively, leads to the amido-imines 4, which are hydrogenated over Raney-Ni to yield simultaneously enantiomerically pure secondary trans- and cis-2-amido-cyclohexane-amines 5 and 6.
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Doi:10.1016/0022-328X(94)80087-1
(1994)Doi:10.1021/ja201092g
(2011)Doi:10.1021/jo00093a018
(1994)Doi:10.1021/jo00094a044
(1994)Doi:10.1002/hlca.19940770137
(1994)Doi:10.1016/S0957-4166(00)86216-3
(1994)