1536
Russ.Chem.Bull., Int.Ed., Vol. 58, No. 7, July, 2009
Sokolov et al.
Table 2 (continued)
Comꢀ
pound
1H
19F
2d
2e
2f
1.11 (t, 3 H, CH3CH2O, J = 7.5); 1.31 (t, 3 H, CH3CH2O, J = 7.7); 4.03 (m, 2 H, CH3CH2O);
4.29 (m, 2 H, CH3CH2O); 6.01 (s, 1 H, NH); 7.12 (m, 3 H, CHAr); 7.28 (m, 2 H, CHAr);
–0.81 (s, CF3)
–0.93 (s, CF3)
1.10 (t, 3 H, CH3CH2O, J = 7.5); 3.95 (s, 3 H, MeO); 4.00 (m, 2 H, CH3CH2O); 5.90
(s, 1 H, NH); 7.10 (m, 3 H, CHAr); 7.25 (m, 2 H, CHAr);
1.10 (t, 3 H, CH3CH2O, J = 7.5); 1.30 (t, 3 H, CH3CH2O, J = 7.6); 4.0 (m, 2 H, CH3CH2O);
4.38 (m, 2 H, CH3CH2O); 6.15 (s, 1 H, NH); 6.95 (m, 2 H, CHAr); 7.11 (m, 2 H, CHAr);
–0.89 (s, 3 F, CF3);
–40.43 (m, 1 F, CFAr
)
)
)
2g
2h
1.15 (t, 3 H, CH3CH2O, J = 7.5); 3.91 (s, 3 H, MeO); 4.02 (m, 2 H, CH3CH2O);
6.01 (s, 1 H, NH); 6.93 (m, 3 H, CHAr); 7.21 (m, 1 H, CHAr);
–1.01 (s, 3 F, CF3);
–33.90 (m, 1 F, CFAr
1.12 (t, 3 H, CH3CH2O, J = 7.5); 3.96 (s, 3 H, MeO); 4.05 (m, 2 H, CH3CH2O);
5.93 (s, 1 H, NH); 6.95 (m, 2 H, CHAr); 7.11 (m, 2 H, CHAr);
–1.03 (s, 3 F, CF3);
–40.08 (m, 1 F, CFAr
3a
3b
1.35 (t, 3 Н, CH3CH2O, J = 7.6); 3.50 (s, 3 H, MeO); 4.45 (q, 2 H, J = 7.6)
–2.30 (s, CF3)
–2.08 (s, CF3)
1.35 (t, 3 Н, CH3CH2O, J = 7.6); 1.35 (t, 3 Н, CH3CH2O, J = 7.9); 4.05 (q, 2 H, CH3CH2O,
J = 7.5) 4.50 (q, 2 H, CH3CH2O, J = 7.9)
3c
3d
1.20 (d, 6 Н, Me2CHO, J = 8.1); 1.41 35 (t, 3 Н, CH3CH2O, J = 7.7); 4.02 (m, 1 Н,
Me2CHO); 4505 (q, 2 H, CH3CH2O, J = 7.5)
–1.92 (s, CF3)
3.11 (s, CF3)
–3.05 (s, CF3)
1.25 (t, 3 Н, CH3CH2O, J = 7.8); 4.40 (q, 2 H, CH3CH2O, J = 7.8); 7.02 (m, 2 H, CHAr);
7.32 (m, 3 H, CHAr
3.86 (s, 3 H, MeO); 7.02 (d, 2 H, CHAr, J = 8.1); 7.12 (m, 1 H, CHAr); 7.31 (m, 2 H, CHAr
3.95 (s, 3 H, MeO); 7.05 (m, 2 H, CHAr); 7.33 (m, 2 H, CHAr
)
3e
3f
)
)
–2.91 (s, 3 F, CF3);
–39.09 (m, 1 F, CFAr
)
)
)
3g
3h
5a
5b
5c
1.30 (t, 3 Н, CH3CH2O, J = 7.7); 4.35 (q, 2 H, CH3CH2O, J = 7.7); 7.12—7.31 (m, 4 H, CHAr
)
–2.94 (s, 3 F, CF3);
–39.28 (m, 1 F, CFAr
3.91 (s, 3 H, MeO); 6.85 (m, 2 H, CHAr); 6.95 (m, 1 H, CHAr); 7.30 (m, 1 H, CHAr
)
–3.12 (s, 3 F, CF3);
–32.62 (m, 1 F, CFAr
1.32 (t, 3 H, CH3CH2O, J = 7.5); 3.56 (s, 3 H, MeO); 4.28 (m, 2 H, CH3CH2O);
7.02 (m, 1 H, CHAr); 7.26 (m, 2 H, CHAr); 7.62 (m, 2 H, CHAr + NH); 7.34 (s, 1 H, NH)
–0.11 (s, CF3)
1.28 (t, 3 H, CH3CH2O, J = 7.5); 3.58 (s, 3 H, MeO); 4.26 (m, 2 H, CH3CH2O); 7.34 (t, 1 H,
CHAr, J = 8.8); 7.68 (m, 3 H, CHAr); 7.88 (s, 1 H, NH); 7.94 (s, 1 H, NH)
17.33 (s, CF3);
0.08 (s, CF3)
1.32 (t, 3 H, CH3CH2O, J = 7.5); 3.57 (s, 3 H, MeO); 4.31 (m, 2 H, CH3CH2O);
7.36 (m, 3 H, CHAr); 7.49 (t, 1 H, CHAr, J = 8.8); 7.66 (m, 3 H, CHAr);
7.88—8.08 (m, 3 H, CHAr + NH + NH)
15.36 (s, CF3);
–0.15 (s, CF3)
5d
5e
1.26 (t, 3 H, CH3CH2O, J = 7.5); 1.32 (t, 3 H, CH3CH2O, J = 7.5); 3.72—3.94 (m, 2 H,
CH3CH2O); 4.31 (m, 2 H, CH3CH2O); 6.64 (s, 1 H, CHAr); 7.12 (m, 1 H, CHAr); 7.28 (m, 2 H,
CHAr); 7.56 (s, 1 H, NH); 7.68 (s, 1 H, NH)
–0.24 (s, CF3)
1.18 (t, 3 H, CH3CH2O, J = 7.5); 1.22 (t, 3 H, CH3CH2O, J = 7.5); 3.72 (m, 1 H, CH3CH2O);
3.98 (m, 1 H, CH3CH2O); 4.28 (m, 2 H, CH3CH2O); 7.23 (m, 2 H, CHAr); 7.37 (s, 1 H, CHAr);
7.81 (s, 1 H, NH); 8.53 (s, 1 H, NH)
–0.46 (s, 3 F, CF3);
–46.61 (m, 1 F, CFAr
)
)
5f
1.18—1.34 (m, 9 H, Me2CHO + CH3CH2O); 4.28 (m, 2 H, CH3CH2O); 4.48 (m, 1 H, Me2CHO); –0.49 (s, 3 F, CF3);
6.56 (s, 1 H, NH); 7.06 (m, 2 H, CHAr); 7.39 (m, 2 H, CHAr); 7.52 (s, 1 H, NH)
–42.70 (m, 1 F, CFAr
5g
1.17 (d, 3 H, Me2CHO, J = 6.8); 1.26 (m, 6 H, Me2CHO + CH3CH2O);
4.27 (m, 2 H, CH3CH2O); 4.55 (m, 1 H, Me2CHO); 7.37 (m, 2 H, CHAr); 7.53 (m, 1 H, CHAr);
7.62 (m, 1 H, CHAr); 7.98 (s, 1 H, NH); 8.60 (s, 1 H, NH)
15.50 (s, CF3);
–0.40 (s, CF3)
5h
1.18—1.32, 1.18—1.34 (m, 9 H, Me2CHO + CH3CH2O); 4.20 (m, 2 H, CH3CH2O);
4.56 (m, 1 H, Me2CHO); 7.34 (d, 1 H, CHAr, J = 8.1); 7.48 (m, 2 H, CHAr); 7.82 (s, 1 H, NH);
7.94 (s, 1 H, NH)
–0.57 (s, CF3)
5i
5j
1.29 (t, 3 H, CH3CH2O, J = 7.2); 4.34 (m, 2 H, CH3CH2O); 7.08—7.29 (m, 8 H, CHAr);
7.38 (s, 1 H, NH); 7.46 (s, 1 H, NH)
19.78 (s, CF3);
0.34 (s, CF3)
1.32 (t, 3 H, CH3CH2O, J = 7.2); 3.88 (s, 3 H, MeO); 4.36 (m, 2 H, CH3CH2O);
0.24 (s, 3 F, CF3);
6.96 (s, 1 H, CHAr); 7.06 (m, 3 H, CHAr); 7.31 (m, 3 H, CHAr + NH); 7.49 (s, 1 H, NH)
–40.58 (m, 1 F, CFAr
)
5k
3.84 (s, 3 H, MeO); 7.05 (m, 2 H, CHAr); 7.22 (m, 3 H, CHAr); 7.38 (s, 1 H, NH);
7.51 (m, 2 H, CHAr); 8.01 (s, 1 H, NH)
15.46 (s, 3 F, CF3);
0.27 (s, 3 F, CF3);
–40.18 (m, 1F, CFAr
)