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17. Apicidin
mp 186-188oC; 1H NMR (300 MHz, CDCl3): 7.56 (1H, d, J = 7.8 Hz), 7.39 (1H, d, J = 8.1 Hz), 7.00 - 7.30 (4H,
m), 6.46 (1H, d, J = 10.2 Hz), 6.42 (1H, d, J = 6 Hz), 5.06 (1H, d, J = 4.5 Hz), 4.73 (1H, t, J = 10.5 Hz), 4.18 (1H,
dt, J = 7.5, 10.0 Hz), 3.90 - 4.10 (2H, m), 4.03 (3H, s), 3.79 (1H, dd, J = 10.5, 10 Hz), 3.45 (1H, dd, J = 6.0, 15.0
Hz), 3.05 (1H, dt, J = 2.4, 13.0 Hz), 2.39 ( 2H, q, J = 7.5 Hz), 2.36 (2H, t, J = 7.5 Hz), 1.05 - 2.20 (17H, m), 1.04
(3H, t, J = 7.5 Hz), 0.92 (3H, t, J = 7.5 Hz), 0.86 (3H, d, J = 6.6 Hz); IR (film) 3271, 1713, 1694, 1667, 1616 cm-1;
HRMS (FAB, NBA) MH+ calcd for C34H50 N5O6 624.3761, found 624.3718; [α]D28 -82.6o (c0.25, CHCl3)