Heterocycles p. 1653 - 1672 (2003)
Update date:2022-07-29
Topics: Synthesis Amides Experimental terms Crystallographic studies Acridinic esters 4-methyl functionalized acridines Efficient synthetic route
Chiron, Julien
Galy, Jean-Pierre
In order to open a new way in antitumor drugs research, an efficient synthetic route to mono functional 4-substitued acridine derivatives has been developed on the basis of direct electrophilic substitution of acridine. This method leads to a wide range of simple acridinic patterns that can be linked to various side chains. We present here the synthesis of two new families of acridine ester and amide derivatives, obtained from acridinic alcohol and amine respectively, with high yields. Some crystallographic aspects of one representative compound of each family are discussed.
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