4
Tetrahedron Letters
Res. 2002, 27, 297; (b) Nogueira, C. W.; Zeni, G.; Rocha, J. B. T. Chem.
radical scavenging activity than other disubstituted diaryl
Rev. 2004, 104, 6255.
15 Apak, R.; Güçlü, K.; Özyürek, M.; Çelik, S. E. Microchim. Acta 2008,
160, 413.
diselenides; however, it did not present DPPH radical scavenging
activity.
16 Rostamizadeh, S.; Aryan, R.; Ghaieni, H. R.; Amani, A. M. Monatsh
Chem. 2008, 139, 1241.
17 (a) Braga, A. L.; Severo, W. A. F.; Schwab, R. S.; Rodrigues, O. E. D.;
Dornelles, L.; Braga, H. C.; Lüdtke, D. S. Tetrahedron Lett. 2009, 49,
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Rocha, J. B. T.; Braga, A. L. Eur. J. Org. Chem. 2009, 25, 4211.
18 Thaipong, K.; Boonprakob, U.; Crosby, K.; Cisneros–Zevallos, L.;
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19 Krishnaraju, A.V.; Rao, C. V.; Rao, V. N.; Reddy, K. N.; Trimurtulu, G.
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Conclusions
Synthesis and scavenging activities of compounds 2-
alkyl/arylchalcogenyl-N-(4-aryl-1,3-thiazol-2-yl)acetamides 5a-r
against ABTS and DPPH radicals were reported. The chosen
methodologies exhibited simplicity and fastness in their
performance, providing products in yields that vary from
moderate to excellent. The methodology also enabled the
synthesis of a number of compounds with different functional
groups. The compounds 5 (m, h, i, f, q, g, l, c, n) were effective
scavengers against ABTS radical species but less effective on
scavenging the DPPH radical, indicating that the antioxidant
effect of these compounds were related to protonated radical
scavenger activity.
20 Luchese, C.; Brandão, R.; Acker, C. I.; Nogueira, C. W. Mol. Cell.
Biochem. 2012, 367, 153.
Acknowledgements
The authors gratefully acknowledge CNPq, CAPES, and
FAPERGS for financial support.
Supplementary data
Supplementary data associated with this article can be found,
in the online version, at
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