Bioorganic and Medicinal Chemistry Letters p. 509 - 513 (2001)
Update date:2022-09-26
Topics:
Chu, Lin
Hutchins, Jennifer E.
Weber, Ann E.
Lo, Jane-Ling
Yang, Yi-Tien
Cheng, Kang
Smith, Roy G.
Fisher, Michael H.
Wyvratt, Matthew J.
Goulet, Mark T.
A nonpeptidyl GnRH receptor antagonist (1), with a unique 2-arylindole core, was identified through the Merck in-house screening for binding affinity on the rat GnRH receptor. SAR studies directed toward the alkoxy-ethanolamine and 2-aryl groups resulted in a simpler lead structure with improved activity. This compound 50 exhibits a 60-fold improvement in binding activity over our initial lead 1.
View MoreSuzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Reliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED
Contact:+86-0532-82683616
Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
JiYi Chemical (Beijing) Co., Ltd.
Contact:+86-10-89385733
Address:Shilou Town of Fangshan District, Beijing
lianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Doi:10.1021/jm00319a033
(1966)Doi:10.1016/0031-9422(71)85033-1
(1971)Doi:10.1002/ejoc.201701783
(2018)Doi:10.1021/jm051059p
(2006)Doi:10.1021/jm000468c
(2001)Doi:10.1016/S0960-894X(02)00380-3
(2002)