Bulletin of the Chemical Society of Japan p. 1969 - 1979 (1995)
Update date:2022-08-04
Topics:
Mataka
Kitagawa
Tsukinoki
Tashiro
Takahashi
Kamata
When heated in an alcoholic solvent, such as ethylene glycol or butanol, 4-substituted 3-aroyl-1-alkylpyrrolidines, which are readily accessible via the condensation of an amino acid, paraformaldehyde, and 3-substituted 1-ary-2-propen-1-one, afforded 4-substituted 1-alkyl-2-aryl-3-methylpyrrole derivatives in good yields. The ring-transformation of 3,4-dibenzoyl-1-methyl-2-phenylpyrrolidine occurred in two directions, giving the corresponding 3-benzyl- and 3-methylpyrrole derivative. Also, bicyclic pyrroles, such as 1H,3H-pyrrolo[1,2-c]thiazole, 2,3-dihydro-1H-pyrrolizine, and 5,6,7,8-tetrahydroindolizine, were prepared by the ring-transformation of bicyclic aroylpyrrolidines obtained from the corresponding cyclic amino acids. A mechanism for the ring-transformation is proposed.
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Doi:10.1002/1099-0682(200105)2001:5<1207::aid-ejic1207>3.0.co;2-4
(2001)Doi:10.1021/jo01058a533
(1962)Doi:10.1007/BF00857422
()Doi:10.1055/s-1985-31264
(1985)Doi:10.1246/cl.1985.755
(1985)Doi:10.1016/S0040-4020(99)01050-9
(2000)