Journal of Medicinal Chemistry p. 1222 - 1226 (1980)
Update date:2022-08-03
Topics:
Glennon, R. A.
Schubert, E.
Jacyno, J. M.
Rosecrans, J. A.
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats.Both 7-Me- and 5-Ome-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-OMe-DMT.Although 7-Et- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallelthose of 5-OMe-DMT.In contrast, 6-OMe-DMT and its 5-OMe derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.
View MoreRudong Zhenfeng Yiyang Chemical Co., Ltd.
Contact:0513-84573047
Address:South Fengli Town, Rudong County, Jiangsu Province, China
Contact:+86-15527136576
Address:Wuhan city
JinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Contact:+86-531-58668191 58668193 58668196 58661173
Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Doi:10.1246/bcsj.57.791
(1984)Doi:10.1021/ol015854i
(2001)Doi:10.1021/ja01556a019
(1958)Doi:10.1016/S0040-4020(01)00133-8
(2001)Doi:10.1039/d0ob02192j
(2021)Doi:10.1016/j.bioorg.2019.03.006
(2019)