Journal of the American Chemical Society
Page 6 of 7
Financial support was provided by the ACS PRF (55108ꢀND1
Figure 4. Activities (IC50 values) of chlorolissoclimide and
analogues against aggressive tumor cell lines (A2058: melanoꢀ
ma; DU145: prostate)
1
2
3
4
to E.J.A.) and the NIH (GMꢀ086483 to C.D.V. and P30 CAꢀ
033572 “Drug Discovery and Structural Biology Core of the
City of Hope Comprehensive Cancer Center” to D.A.H.).
R.K.Q. thanks the NSF for a Graduate Research Fellowship and
Y.S. was supported by a Feodor Lynen Postdoctoral Fellowship
from the Humboldt Foundation.
5
ꢀ
CONCLUSION
6
7
In conclusion, we report a practical, siteꢀselective apꢀ
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ASSOCIATED CONTENT
Supporting Information. Experimental procedures and spectral
data for all new compounds, and full descriptions of the syntheꢀ
ses of compounds 36, 45, and 46, This material is available free
AUTHOR INFORMATION
Corresponding Author
*cdv@uci.edu; *eja@email.unc.edu
‡These authors contributed equally.
The authors declare no competing financial interests.
ACKNOWLEDGMENT
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