Journal of Medicinal Chemistry p. 1358 - 1363 (1980)
Update date:2022-08-03
Topics:
Koga, Hiroshi
Itoh, Akira
Murayama, Satoshi
Suzue, Seigo
Irikura, Tsutomu
Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.
View MoreDANYANG ZHONGTAI TRADE CO .,LTD.
Contact:0086-511-86985511
Address:No.25,Dongfang Rd., Danyang City.Jiangsu P.R.China
China Synchem Technology Co.,Ltd
website:http://www.cnsynchem.com
Contact:+86-0552-4929311
Address:No.217 Daqing Road
Anhui Dexinjia Biopharm Co., Ltd
Contact:+86-531-82375818
Address:9 Hexie Road, kaifaqu, Taihe
Contact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Contact:+86-134-5286-9121
Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
Doi:10.1002/1521-3773(20010401)40:7<1216::AID-ANIE1216>3.0.CO;2-W
(2001)Doi:10.3987/COM-01-9168
(2001)Doi:10.1039/b009599k
(2001)Doi:10.1016/j.ica.2007.02.037
(2008)Doi:10.1016/S0022-328X(00)82919-8
(1972)Doi:10.1039/C29710001454
(1971)