Bioorganic Chemistry p. 19 - 26 (2018)
Update date:2022-08-03
Topics:
Qazi, Syeda Uroos
Rahman, Shafiq Ur
Awan, Asia Naz
al-Rashida, Mariya
Alharthy, Rima D.
Asari, Asnuzilawati
Hameed, Abdul
Iqbal, Jamshed
A series of hydrazinecarboxamide derivatives were synthesized and examined against urease for their inhibitory activity. Among the series, the 1-(3-fluorobenzylidene)semicarbazide (4a) (IC50 = 0.52 ± 0.45 μM), 4u (IC50 = 1.23 ± 0.32 μM) and 4h (IC50 = 2.22 ± 0.32 μM) were found most potent. Furthermore, the molecular docking study was also performed to demonstrate the binding mode of the active hydrazinecarboxamide with the enzyme, urease. In order to estimate drug likeness of compounds, in silico ADME evaluation was carried out. All compounds exhibited favorable ADME profiles with good predicted oral bioavailability.
View Moreshijiazhuang shuanglian chemical industry co.,ltd
Contact:0311-82190302
Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway,Shijiazhuang City
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Huaihua Baohua Biotechnology Co.,Ltd
website:http://www.baochengchem.com
Contact:86-519-82698291
Address:HouYang chemical development zone,Jintan,Jiangsu,China (213200)
Contact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Contact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Doi:10.1246/bcsj.60.3423
(1987)Doi:10.1016/S0040-4039(00)79257-4
(1993)Doi:10.1021/ja00752a019
(1971)Doi:10.1002/chem.201800474
(2018)Doi:10.1007/BF00479937
()Doi:10.1055/s-0037-1610658
(2018)