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Organic & Biomolecular Chemistry
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Journal Name
COMMUNICATION
products (5g-5h) in high yields. In addition, reaction of
propiophenone with R-5 took place giving 1-phenyl-2-
thiocyanatopropan-1-one (5i) in 82% yield.
Conclusions
DOI: 10.1039/C9OB01340G
In summary, we successfully prepared a new electrophilic
thiocyanating reagent R-5 and demonstrated the anticipated
enhanced reactivity. In absence of any catalysts and additives R-
5
readily reacted with a variety of phenols, indoles, anilines,
Table 3 Thiocyanation reaction of ketones derivatives
anisoles, hetero aromatics, and alkenes in high yields under
mild reaction conditions. In presence of TfOH and Lewis acid,
reactions of unactivated arenes and electron-deficient
heterocycle with R-5, and ketones afforded thiocyanation
products in good yields, respectively. The reaction of terminal
alkenes and asymmetric variant was under way in our group.
Conflicts of interest
There are no conflicts to declare
Acknowledgement
The authors thank NSFC financial support (201572020).
a Reaction conditions: ketones (0.20 mmol), R-5 (141 mg, 0.4 mmol, 2.0 equiv),
Zn(OTf)2 (14.5 mg, 0.04 mmol, 0.2 equiv), CH3CN (1.0 mL), 40 oC, 24 h.
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