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We gratefully acknowledge the financial support from the R. S. Wolfson
Fellowship (to S.V.L. and I.R.B.),Natural Sciences and Engineering Re-
search Council of Canada for a Postdoctoral Fellowship (to G.K.T.),
GlaxoSmithKline (to C.M.G.J.) and the BP endowment and the Novartis
Research Fellowship (to S.V.L.). We also thank Dr. Steve Smith at Syn-
genta for supplying images contained in Figure 1.
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Received: November 10,2005
Published online: April 4,2006
4416
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Chem. Eur. J. 2006, 12,4407 – 4416