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chromatography (TLC) confirmed that both the starting
materials were completely reacted. The solid was washed
with hot water to remove piperazine from the reaction
mixture and filtered. The yield of the product was quanti-
tative ([98 %) and identified as 9a (R=Ph) by comparison
of its melting point with those in the literature. In a similar
procedure, dimedone and piperazine (1:1) were reacted
together in a ball-mill container for 15 min. The reaction
was completed as revealed by TLC. The crude product was
reacted with 9a in a ball-mill for 15 min at room temper-
ature. After washing with hot water, filtration, and drying,
the product was identified as 6a with quantitative yield.
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1
1,683, 1,604, 1,286, 1,257, 1,224, 1,070 cm-1; H NMR
(500 MHz, CDCl3): d = 1.11 (t, 3H, J = 7.1 Hz), 2.42 (d,
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Acknowledgments We acknowledge Iran University of Science
and Technology (IUST) for financial support of this work and Prof.
Gerd Kaupp from the University of Oldenburg, Germany, for his kind
donation of some of the chemicals and the ball-mill apparatus.
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