Bioorganic and Medicinal Chemistry Letters p. 2455 - 2458 (2016)
Update date:2022-08-05
Topics:
Shchegol'Kov, Evgeny V.
Shchur, Irina V.
Burgart, Yanina V.
Saloutin, Victor I.
Solodnikov, Sergey Yu.
Krasnykh, Olga P.
Kravchenko, Marionella A.
We have developed the practical method for polyfluorosalicylic acids synthesis via nucleophilic ortho-mono-substitution of fluorine atom with magnesium methoxide. We have managed to increase the yield of targeted polyfluorosalicylic acids from good to quantitative. We have studied the tuberculostatic activity of polyfluorosalicylic acids. It has been found that minimum inhibitory concentration (MIC) of compounds is from 0.7 to 6.5 μg/mL depending on the structure.
View MoreWuhan Silworld Chemical Co.,Ltd
website:http://www.silworldchemical.com
Contact:+86-27-85613400
Address:No.198 jiangjun Road, Wuhan,China 430033
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.
Contact:+86-186-02659358
Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
website:http://www.konochem.com
Contact:86-29-86107037-8015
Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Doi:10.1007/s00706-018-2227-6
(2018)Doi:10.1021/jo00098a019
(1994)Doi:10.1002/chem.202001990
(2020)Doi:10.1021/acs.joc.9b01505
(2019)Doi:10.1021/jo01106a050
(1958)Doi:10.1021/jo01075a017
(1960)