Synthetic Communications p. 923 - 937 (1997)
Update date:2022-08-03
Topics:
Kiessling, Anthony J.
McClure, Cynthia K.
An efficient two step transformation of 1°and 2°amides to methyl and ethyl esters has been developed using trimethyl- and triethyloxonium tetrafluoroborates, and dilute acid. This methodology was applied to 1-benzyl-4-phenylamino-4-piperidinecarboxamide, a precursor in the synthesis of carfentanil, to produce the methyl ester in 60% yield and the ethyl ester in 80% yield.
View MoreHangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Rizhao Lanxing Chemical Indusrial Co.,Ltd
Contact:86-633-2616708
Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Shanghai Taibao Pharmaceutical Technology Co., Ltd
Contact:021-52217366
Address:shanghai
Doi:10.1021/ja012009m
(2001)Doi:10.1246/bcsj.39.2707
(1966)Doi:10.1016/S0040-4039(01)01624-0
(2001)Doi:10.1021/ja050974x
(2005)Doi:10.1002/jccs.200800206
(2008)Doi:10.1021/ol010257h
(2001)