Bioorganic and Medicinal Chemistry Letters p. 5070 - 5076 (2013)
Update date:2022-08-05
Topics:
Chen, Shoujun
Sun, Lijun
Koya, Keizo
Tatsuta, Noriaki
Xia, Zhiqiang
Korbut, Timothy
Du, Zhenjian
Wu, Jim
Liang, Guiqing
Jiang, Jun
Ono, Mitsunori
Zhou, Dan
Sonderfan, Andrew
A series of N′1,N′3-dialkyl- N′1,N′3-di(alkylcarbonothioyl) malonohydrazides have been designed and synthesized as anticancer agents by targeting oxidative stress and Hsp70 induction. Structure-activity relationship (SAR) studies lead to the discovery of STA-4783 (elesclomol), a novel small molecule that has been evaluated in a number of clinical trials as an anticancer agent in combination with Taxol.
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