10.1002/anie.202003614
Angewandte Chemie International Edition
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(E/Z)-6 but in all cases no reaction was observed.
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When R in compound 2 was a hydrogen atom the rearrangement did not
take place and alkylation processes dominated.
Single crystal X-ray diffraction data were collected using a (Rigaku)
Oxford Diffraction SuperNova diffractometer for 4a and Diamond Light
Source Beamline I19 for 4l and 4n. Structures were solved using
'Superflip’ [L. Palatinus, G. Chapuis, J. Appl. Cryst., 2007, 40, 786.]
before refinement with CRYSTALS [a) P. Parois, R. I. Cooper, A. L.
Thompson, Chem. Cent. J., 2015, 9:30. (b) R. I. Cooper, A. L. Thompson,
D. J. Watkin J. Appl. Cryst. 2010, 43, 1100] as per the SI (CIF).
Crystallographic data have been deposited with the Cambridge
Crystallographic Data Centre (CCDC 1986405-07) and can be obtained
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optimization studies it was observed that hydroxide-bases gave the
product 4 in very low yields, making a nucleophilic ring opening of enone
intermediates and subsequent reaction unlikely. Related attempts to
open the cyclopropane ring of ketones such as A with nucleophiles met
with failure.
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