Journal of Medicinal Chemistry p. 65 - 72 (1974)
Update date:2022-08-03
Topics:
Carnmalm
Jacupovic
Johansson
et al.
A series of spiro compounds structurally related to the common tricyclic antidepressants has been tested as inhibitors of the neuronal reuptake of noradrenaline and 5 hydroxytryptamine. Also, some behavioral tests have been performed. Two of the substances, N,N dimethylspiro [5H dibenzo[a,d]cycloheptene 5,1' cyclohex 2' en] 4' amine and N,N dimethylspiro [5H dibenzo[a,d]cycloheptene 5,1' cyclohexan] 4' amine, are very active in the NA uptake inhibition assay. A discussion on structure activity relationships is given.
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Doi:10.1023/A:1014086507352
(2001)Doi:10.1139/v73-120
(1973)Doi:10.1039/c7ob02066j
(2017)Doi:10.1081/SCC-100105322
(2001)Doi:10.1055/s-2002-19321
(2002)Doi:10.1002/cmdc.201100606
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