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2H, J = 7.3 Hz, -CH2), 7.34–7.62 (m, 4H, Aryl-H), 8.31 (s, 1H, amide-NH), 10.09 (s, 1H, amide-NH);
elemental analysis: C16H21N2O2Cl; calculated: C 62.17%, N 9.06%, H 6.80%;found: C 62.50%, N 9.00%,
H 7.13%.
3.1.4. N-cyclohexyl-N0-(pyridin-4-yl)butanediamide) (2c)
Dark maroon solid; yield 25%; m.p 125–127 ◦C; FTIR cm−1:3296(N-H), 1685(C=O), 2927(C-H);
1H-NMR (DMSO-d6, 300 MHz,
δ ppm):1.36–1.74 (m, 11H, cyclo-H), 2.60(t, 2H, J = 7.3 Hz, -CH2), 2.91(t,
2H, J = 7.2 Hz, -CH2), 7.35–8.51(m, 4H, pyridine-H), 9.64(s, 1H, amide-NH), 11.48 (s, 1H, amide-NH);
elemental analysis: C15H21N3O2; calculated: C 65.37%, N 15.25%, H 7.62%; found: C 66.12%, N 15.59%,
H 7.92%.
3.1.5. N-cyclohexyl-N0-(4-methoxyphenyl)butanediamide) (2d)
Off-white solid; yield 55%; m.p 180–182◦C; FTIR cm−1: 3271(N-H), 1661(C=O), 2924(C-H);
1H-NMR (DMSO-d6, 300 MHz,
δ ppm): 1.19–1.14(m, 11H, cyclo-H), 2.59 (t, 2H, J = 7.2 Hz,-CH2), 2.70(t,
2H, J = 7.4 Hz, -CH2), 3.79(s, 3H, -OCH3), 5.77 (d, 1H, J = 6.6 Hz), 7.45–6.83 (m, 4H, Aryl-H), 8.31(s,
1H, amide-NH); elemental analysis: C17H24N2O3; calculated: C 67.02%, N 9.19%, H 7.88%; found: C
67.13%, N 8.98%, H 8.19%.
3.1.6. N-cyclohexyl-N0-(3-methoxyphenyl butanediamide) (2e)
Dark brown solid; yield 56%; m.p 130–133 ◦C; FTIR cm−1: 3296(N-H), 1664(C=O), 2920(C-H);
1H-NMR (DMSO-d6, 300 MHz,
δ ppm): 1.10–1.45 (m, 11H, cyclohexyl-H), 2.68 (t, 2H, J = 7.2 Hz, -CH2),
2.84 (t, 2H, J = 7.3 Hz, -CH2), 3.70 (s, 3H, -OCH3), 6.96–7.62 (m, 4H, Aryl-H), 7.11(s, 1H, amide-NH),
8.89(s, 1H, amide-NH); elemental analysis: C17H24N2O3; calculated: C 67.02%, N 9.19%, H 7.88%;
found: C 66.91%, N 9.20%, H 7.51%.
3.1.7. N-cyclohexyl-N0-(2-methoxyphenyl)butanediamide) (2f)
Light yellow solid; yield 38% 140–142 ◦C FTIR cm−1:3314(N-H), 1669(C=O), 2851(C-H); 1H-NMR
(DMSO-d6, 300 MHz, δ ppm): 1.29–1.87(m, 11H, cyclohexyl-H), 2.38(t, 2H, J = 7.4 Hz, -CH2), 2.94(t,
2H, J = 7.5 Hz, -CH2),3.68(s, 3H,-OCH3),), 7.17-7.33 (m, 4H, Aryl-H),9.86 (s, 1H, amide-NH), 11.42 (s,
1H, amide-NH); elemental analysis: C17H24N2O3; calculated: C 67.02%, N 9.19%, H 7.88%; found: C
67.23%, N 9.31%, H 7.05%.
3.1.8. N-benzyl-N0-cyclohexylbutanediamide (2g)
◦
1
Yellow solid; yield 66% 180–182 C; FTIR cm−1: 3285(N-H), 1662(C=O), 2921(C-H); H-NMR
(DMSO-d6, 300 MHz, ppm 1.41–1.77(m, 11H, cyclohexyl-H), 2.60(t, 2H, J = 7.4 Hz, -CH2), 2.79(t,
δ
2H, J = 7.4 Hz, -CH2), 4.50(s, 2H, -CH2), 7.23–7.86(m, 4H, Aryl-H), 7.19(s, 1H, amide-NH), 7.91(s, 1H,
amide-NH); elemental analysis: C17H24N2O2; calculated: C 70.7%, N 9.70%, H 8.32%; found: C 71.06%,
N 9.60%, H 7.95%.
3.1.9. N-cyclohexyl-N0-(4-hydroxyphenyl)butanediamide (2h)
Off-white solid; yield 30% 155–156◦C; FTIR cm−1: 3309(N-H), 1675(C=O), 2855(C-H); 1H-NMR
(DMSO-d6, 300 MHz, δ ppm): 1.40–1.79(m, 11H, cyclohexyl-H), 2.69(t, 2H, J = 7.3 Hz, -CH2), 2.86(t,
2H, J = 7.4 Hz, -CH2), 6.36(s, 1H, OH), 6.61–7.13(m, 4H, Aryl-H),7.84(s, 1H, amide-NH), 8.47(s, 1H,
amide-NH); elemental analysis: C16H22N2O3; calculated: C 66.12%, N 9.64%, H 7.57%; found: C
66.51%, N 9.35%, H 8.01%.
3.1.10. N,N0-di cyclohexyl butanediamide (2i)
1
White solid; yield 68% 140–142◦C; FTIR cm−1:3284(N-H), 1670 (C=O), 2853(C-H); H-NMR
(DMSO-d6, 300 MHz, δ ppm): 1.56–1.68(m, 11H, cyclohexyl-H), 1.70–1.89(m, 11H, cyclohexyl-H), 2.62(t,