Carbamates as Histamine H3 Receptor Antagonists
J ournal of Medicinal Chemistry, 1996, Vol. 39, No. 5 1163
pig ileum by standard methods described by Hirschfeld et al.40
Each pharmacological test was performed at least in triplicate,
but the exact type of receptor interaction was not determined
in each case. The given values represent the mean.
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Ack n ow led gm en t. We are grateful to S. Reidemei-
ster for the preparation of compounds 11, 14, and 24.
Clobenpropit41 was kindly donated by Prof. H. Timmer-
man (Amsterdam, The Netherlands). This work was
supported by the Biomedical & Health Research Pro-
gramme BIOMED I of the European Union (PL 921087)
and the Verband der Chemischen Industrie, Fonds der
Chemischen Industrie (Frankfurt/Main, Germany).
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