European Journal of Medicinal Chemistry p. 287 - 292 (1989)
Update date:2022-08-04
Topics:
Caujolle, Raymond
Amarouch, Hamid
Payard, Marc
Loiseau, Philippe R.
Bories, Christian
et al.
New compounds with thiazoline or dihydrothiazine rings substituted by alkylamino or arylamino groups were synthesized and screened in vitro against three Nematodes.Inhibition of fumarate-reductase activity was also evaluated.For all in vitro anti-parasitic tests, dihydrothiazines were more potent than corresponding thiazolines derivatives, however, thiazolines showed a greater inhibition of fumarate-reductase.
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