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In conclusion, an unprecedented, mild and catalyst-free visible-
light protocol for C-H acylation of N-heterocycles was devel-
oped. Remarkably, the energy from visible-light is harnessed in
the absence of any external photosensitizer, arguably via for-
mation of photoactive EDA complexes, thus inducing for-
mation of the acyl radical and subsequent C-C bond formation
event. The scope of this radical reaction is wide, with respect to
both acyl-derivatives and N-heterocyles, clearly showing its
appealing synthetic features. Accordingly, this strategy paves
the way toward mild, operationally simple and environmentally
benign synthesis of biologically relevant isoquinoline alkaloids.
We thank the CNRS (Centre National de la Recherche Scien-
tifique), the "Ministère de l'Education Nationale et de la Re-
cherche", ANR (Agence Nationale de la Recherche) France for
financial support. L. Guillemard acknowledges the ANR for a
doctoral grant "2al-VisPhot-CH" N° ANR-15-CE29-0004-01.
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