Bioorganic and Medicinal Chemistry Letters p. 1709 - 1713 (2002)
Update date:2022-07-29
Topics:
Lin, Yun-Loung
Huang, Jian-Lin
Wu, Chung-Shieh
Liu, Hung-Ge
Yang, Ding-Yah
An epoxybenzoquinone, 4-hydroxyphenoxypropionic acid, and 2-hydroxy-3-phenyl-3-butenoic acid derivatives have been designed, synthesized, and evaluated for in vitro inhibition activity against 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver by the spectrophotometric enol-borate method. The biological data demonstrated that neither epoxybenzoquinone ester nor 2-hydroxy-3-phenyl-3-butenoic acid is an inhibitor of 4-HPPD. The most potent 4-HPPD inhibitor tested was 3-hydroxy-4-phenyl-2(5H)-furanone with an IC50 value of 0.5 μM, which may serve as a lead compound for further design of more potent 4-HPPD inhibitors.
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Doi:10.1016/S0040-4039(02)01717-3
(2002)Doi:10.1021/ol0271990
(2002)Doi:10.1023/A:1016079221645
(2002)Doi:10.1021/ol016924o
(2002)Doi:10.1016/S0040-4039(01)89120-6
(1965)Doi:10.1081/SCC-120014976
(2002)