Molecules (2021)
Update date:2022-08-03
Topics: Microwave-assisted synthesis Piperidine Pyrrolidine Structural characterization Morpholine Aminopyridine Assessment of the antibacterial activity Acetamides
Abdulghani, Saba S.
Alsamarrai, Abdulmajeed S. H.
A series of new acetamide derivatives 22–28 of primary and secondary amines and para-toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two Gram-negative bacterial species such as S. pyogenes, E. coli, and P. mirabilis using the Mueller-Hinton Agar diffusion (well diffusion) method. The synthesized compounds with significant differences in inhibition diameters and MICs were compared with those of amoxicillin, ampicillin, cephalothin, azithromycin and doxycycline. All of the evaluated acetamide derivatives were used with varying inhibition concentrations of 6.25, 12.5, 37.5, 62.5, 87.5, 112.5 and 125 μg/mL. The results show that the most important antibacterial properties were displayed by the synthetic compounds 22 and 24, both of bear a para-chlorophenyl moiety incorporated into the 2-position moiety of acetamide 1. The molecular structures of the new compounds were determined using the FT-IR and1H-NMR techniques.
View MoreJiangsu Haian Petro chemical Plant
Contact:+86-513-88902723
Address:99, Changjiang West Road, Haian County, Jiangsu
WUHAN CHEMPROSPECT PHARMTECH CO., LTD
website:http://www.chemprospect.com
Contact:+86--27-84984898
Address:No. 2, Road, East Lake Hi-tech Development Zone, Wuhan, China
Rudong Zhenfeng Yiyang Chemical Co., Ltd.
Contact:0513-84573047
Address:South Fengli Town, Rudong County, Jiangsu Province, China
Xinxiang Hongqi District Houyuan Trading Co., Ltd
Contact:86-373-3695376
Address:Xinxiang City, Henan Province, China
Shuanghe Bio-Technology Limited
Contact:+86-571-61710758,18968016640
Address:Jinqiao north road 916# Fuyang
Doi:10.1016/S0040-4039(01)80756-5
(1989)Doi:10.1515/znb-2019-0091
(2019)Doi:10.1248/cpb.58.825
(2010)Doi:10.1021/ja109734e
(2011)Doi:10.1021/om100978w
(2011)Doi:10.1016/S0040-4020(01)81089-9
(1989)