Organic Process Research and Development p. 1252 - 1256 (2019)
Update date:2022-08-04
Topics:
Pramanik, Chinmoy
Bapat, Kiran
Patil, Pradip
Kotharkar, Sandeep
More, Yogesh
Gotrane, Dinkar
Chaskar, Sudhir P.
Mahajan, Ulhas
Tripathy, Narendra K.
An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.
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