Journal of Medicinal Chemistry p. 396 - 403 (1974)
Update date:2022-08-02
Topics:
Cricchio
Lancini
Tamborini
Sensi
The synthesis of the oximes of 3 formylrifamycin SV and the preparation of some of the O substituted hydroxylamine intermediates are described. The chemical and physical characteristics, the antibacterial activity on wild type and rifampicin resistant strains, and other biological properties of the new derivatives are reported. Structure activity relationships show that increasing the lipophilicity of the oxime substituent decreases the antibacterial activity, both in vitro and in experimental infection, whereas inhibition of a rifampicin resistant strain of S. aureus and of several transcribing enzymes is increased.
View MoreHangzhou Gangjin Chemical Co.,Ltd.
Contact:+86-571-85109780
Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
Zibo Fuxi'er Chemical Co.,Ltd (Shanxian Fuxi'er Chemical Co.,Ltd)
Contact:+86-533-2091422
Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Engineering Research Center of Pesticide, Heilongjiang Province
Contact:+86-451-86609001
Address:No.74 of Xuefu Road, Nangang District,
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
Doi:10.1021/om030065l
(2003)Doi:10.1021/om020934r
(2003)Doi:10.1002/jms.3641
(2015)Doi:10.1691/ph.2008.7302
(2008)Doi:10.1007/BF00758402
()Doi:10.1039/jr9350001563
(1935)