Journal of Medicinal Chemistry p. 8114 - 8133 (2020)
Update date:2022-08-15
Topics:
Abdelkafi, Hajer
Michau, Aurélien
Pons, Valérie
Ngadjeua, Flora
Clerget, Alexandra
Ait Ouarab, Lilia
Buisson, David-Alexandre
Montoir, David
Caramelle, Lucie
Gillet, Daniel
Barbier, Julien
Cintrat, Jean-Christophe
High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.
View MoreTianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
ZHANGJIAGANG FREE TRADE ZONE YONG HAN INTERNATIONAL TRADING CO., LTD
Contact:86 512 57910558
Address:qianjin M road
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Jinan Jianfeng Chemical Co., Ltd
Contact:0086-531-88110457
Address:sales01(-a-t-)pharmachemm{dot}c+o+m
Huludao Tianqi Shengye Chemical Co.,Ltd.
Contact:0086 429 2075777
Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Doi:10.1016/S0968-0896(02)00458-3
(2003)Doi:10.1016/S0040-4020(01)97532-5
(1974)Doi:10.1016/j.tetlet.2005.12.097
(2006)Doi:10.1016/S0040-4039(03)00418-0
(2003)Doi:10.1016/S0040-4020(97)10356-8
(1998)Doi:10.1111/1468-0483.00178
(1910)