10.1002/anie.201808320
Angewandte Chemie International Edition
COMMUNICATION
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[10] Reaction profiles using 5a and 5b, as well in the absence of catalyst,
were also monitored (see Scheme S1 in the Supporting Information
for details).
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[13] At this stage, all efforts to recover or detect catalysts 5 following
their reactions have failed. However, we believe that trans-
cyclooctenes 5 act as catalysts on the basis of the reasonable reaction
profiles displayed in Scheme S1 and the results of control
experiments summarized in Table 1 and Table S1 in the Supporting
Information.
[14] At this stage, optically active forms of trans-cyclooctenes 5 failed to
realize enantioselectivity in the halolactonization reactions presented
herein (see Scheme S3 in the Supporting Information for details).
We are currently optimizing catalyst structures for asymmetric
catalysis in our laboratory.
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