Journal of Organic Chemistry p. 2941 - 2950 (2019)
Update date:2022-09-26
Topics:
Huang, Wenbo
Xu, Jing
Liu, Changhui
Chen, Zhiyan
Gu, Yanlong
2,3-Disubstituted benzofurans were synthesized from acrolein dimer and 1,3-dicarbonyl compounds by using N-bromosuccinimide as an oxidizing agent. The method was used to synthesize two commercial drug molecules, benzbromarone and amiodarone. The proposed mechanism of the reaction involves a N-bromosuccinimide (NBS)-assisted autotandem catalysis with Lewis acid catalyst. To proof the proposed mechanism, an intermediate was isolated successfully, which can be converted to 4,5,6,7-tetrahydrobenzofurans.
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Doi:10.1016/0040-4020(82)80173-7
(1982)Doi:10.1021/ja0176705
(2002)Doi:10.1021/ol403644n
(2014)Doi:10.1016/S0277-5387(98)00135-1
(1998)Doi:10.1021/jm00369a020
(1984)Doi:10.1016/S0040-4039(00)86730-1
(1982)