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Scheme 1. The studies for reaction pathway.
Acknowledgments. This research was supported by INNO-
POLIS Gwangju funded by the Ministry of Science, ICT &
Future Planning (13GJI1331). Spectra data were obtained
from the Korea Basic Science Institute, Gwangju branch.
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Figure 1. Synthesis of isoindolin-1-one from a variety of aryl alkynyl
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marin that was formed in the reaction with 2-iodobenzoic acid
and phenyl propiolic acid.
However, 2-chlorobenzamide provided cyclized product
3aa (Scheme 1(b)).9 These results suggested that 2-
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form isoindolinone (Scheme 1(c)). In addition, amide group
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In conclusion, we report an efficient one-pot method for the
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iodide as a catalyst and cesium carbonate as a base. The
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Bull. Korean Chem. Soc. 2015, Vol. 36, 1745–1746
© 2015 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim