Bioorganic and Medicinal Chemistry Letters p. 4228 - 4231 (2007)
Update date:2022-08-05
Topics:
Pegurier, Cecile
Collart, Philippe
Danhaive, Pierre
Defays, Sabine
Gillard, Michel
Gilson, Frederic
Kogej, Thierry
Pasau, Patrick
Van Houtvin, Nathalie
Van Thuyne, Marc
van Keulen, BerendJan
The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.
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Doi:10.1016/S0960-894X(02)01083-1
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