LETTER
Microwave-Assisted Parallel Synthesis of a 2-Aryl-1H-Isoindole-1,3-Dione Library
345
Scheme
(7) (a) Chandrasekhar, S.; Padmaja, N. B.; Raza, A. Synlett
methodology, with good yields, fast reaction times, and
general applicability to substrates bearing a wide variety
of substituents.
1999, 1597. (b) Chandrasekhar, S.; Takhi, M.; Uma, G.
Tetrahedron Lett. 1997, 38, 8089.
(8) Borah, N. H.; Boruah, R. C.; Sandhus, J. S. J. Chem. Res.(S)
1998, 272.
(9) Parallel synthesis in microwave ovens has been described to
prepare thioamide and pyridine libraries: (a) Olsson, R.;
Hansen, H. C.; Andersson, C.-M. Tetrahedron Lett. 2000,
41, 7947. (b) Cotterill, I. C.; Usyatinsky, A. Y.; Arnold, J.
M.; Clark, D. S.; Dordick, J. S.; Michels, P. C.; Khmelnitsky,
Y. L. Tetrahedron Lett. 1998, 39, 1117.
Acnowledgement
Authors acknowledge support of this work by the Comisión Inter-
ministerial de Ciencia y Tecnología (CICYT) through the project
2FD1997-1248.
(10) Microwave irradiation was carried out with a Sanyo
microwave oven (EM-S100, 800, with a maximum power
output of 800 W) calibrated by a standard procedure:
Watkins, K. W. J. Chem. Ed. 1983, 60, 1043.
(11) Acquired from International Sorbent Technology Ltd., U.K.
(12) Savant Automatic Environmental SpeedVac (AES 2000)
was used.
(13) Microsoft® Excel 97 was used.
(14) Shibata, Y.; Sasaki, K.; Hashimoto, Y.; Iwasaki, S. Chem.
Pharm. Bull. 1996, 44, 156.
(15) Kamal, A.; Laxman, E.; Laxman, N.; Rao, V. Tetrahedron
Lett. 1998, 39, 8733.
(16) Pagani, G.; Baruffini, A.; Borgna, P.; Caccialanza, G.
Farmaco, Ed. Sci. 1968, 23, 448; Chem. Abstr. 1969, 69,
43588.
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Synlett 2002, No. 2, 343–345 ISSN 0936-5214 © Thieme Stuttgart · New York