Bioorganic and Medicinal Chemistry Letters p. 3785 - 3787 (2013)
Update date:2022-08-02
Topics:
Chen, Jinglei
Sun, Weizhen
Yang, Jingjing
Sun, Huan
Wang, Zhixia
Dong, Lanlan
Qiao, Chunhua
Xia, Chao-Ming
Analogues of pyrrolo-[1,2,5]benzothiadiazepine were prepared and evaluated against Schistosoma japonica. The biological data revealed that most benzothiazepine derivatives show anti-schistosomal activity to some extent, while α-chloronation of the title compound and another bioisosteric derivative pyrrolo-[1,2,5]benzodiazepine displayed the most distinct worm killing activity. This study proved that benzodiazepine may serve as a novel structural skeleton for the development of anti-schistosomal agents.
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