Tetrahedron Asymmetry p. 3485 - 3487 (2004)
Update date:2022-08-05
Topics:
Bourdon, Lisa H.
Fairfax, David J.
Martin, Gregory S.
Mathison, Casey J.
Zhichkin, Pavel
A method for the preparation of (2R,3S) nitrogen protected arylserine esters is described. The method consists of rhodium mediated insertion of tert-butylcarbamate into the corresponding 3-keto-2-diazoester, affording the N-protected α-amino-β-ketoester, followed by asymmetric reduction/dynamic resolution to afford the corresponding N-protected 3-arylserine esters in good chemical yield, and in most cases high enantiomeric excess.
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