Chemistry of Heterocyclic Compounds p. 196 - 201 (1982)
Update date:2022-08-05
Topics:
Vysochin
Shishkin
The introduction of substituents with various inductive constants in the 2 position of the diazabicyclo]2.2.2]octane ring gives rise to a change in the pKa values and affects the ease of introduction of a methyl group in the 1 and 4 positions, as well as the rate of demethylation of the bisquaternary salts from the 1 position. When 1,4-diazabicyclo[2.2.2]octane is treated with a sufficiently strong nucleophile, the ring is opened to give a piperazine derivative.
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