Green Chemistry p. 3499 - 3502 (2016)
Update date:2022-08-04
Topics:
Teong, Siew Ping
Yu, Dingyi
Sum, Yin Ngai
Zhang, Yugen
A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide has been developed. The reaction proceeds via sp3 C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity.
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