5
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bacteria like B. subtilis and Escherichia coli. Several of them e.g.
4a, 4b and 4d also showed potent antifungal activities against
Fusarium recini comparable to the broad spectrum protectant
fungicide mancozeb. Overall, this research highlighted not only
the usefulness of Buchwald’s strategy to N-heteroarene system
but also the utility of (triazolo)pyridine / pyrimidine framework
for the discovery and development of new and potent
antimicrobial agents.
9. For a review, see: (a) Khanapur, M.; Alvala, M.; Prabhakar, M.;
Kumar, K. S.; Edwin, R. K.; Saranya, P. S. V. K. S.; Patel, R. K.;
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Acknowledgements
10. For selected synthesis of polysubstituted [1,2,3]triazolo[4,5-
b]pyridines, see: (a) Pokhodylo, N. T.; Shyyka, O. Y. Synth.
Commun. 2017, 47, 1096-1101; (b) Vaughan, J. R.; Krapcho, J.;
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5.
Authors thank the Department of Chemistry, Acharya
Nagarjuna University for research facilities, KALAM BIOTECH
PRIVATE LIMITED, Hyderabad India and Dr. Pallavi Cheguru
(Dept of biosciences, Sri Sathya Sai Institute of Higher Learning,
Anantapur, India) for anti-fungal and anti-bacterial assay.
11. For the selected synthesis of polysubstituted [1,2,3]triazolo[4,5-
d]pyrimidines, see: (a) Li, Z.-H.; Yang, D.-X.; Geng, P.-F.; Zhang,
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Supplementary data
Supplementary data associated with this article can be found,
in the on line version, at xxxxxxxxx
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