Bioorganic and Medicinal Chemistry Letters p. 3797 - 3800 (2003)
Update date:2022-09-26
Topics:
Boschelli, Diane H.
Ye, Fei
Wu, Biqi
Wang, Yanong D.
Barrios Sosa, Ana Carolina
Yaczko, Deanna
Powell, Dennis
Golas, Jennifer M.
Lucas, Judy
Boschelli, Frank
Several 7-alkoxy-4-anilino-3-quinolinecarbonitriles were synthesized and evaluated for Src kinase inhibitory activity. Optimal inhibition of both Src enzymatic and cellular activity was seen with analogues having a 2,4-dichloro-5-methoxyaniline group at C-4. Compound 18, which has a 1-methylpiperidinemethoxy group at C-7, showed in vivo activity in a xenograft model.
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