RSC Advances
Paper
In summary, we have described the construction of an
original system that combines azobenzene-based chromo-
phores with the cyclen coordinating unit and the targeting
cRGD peptide moiety in ve easy-to-perform and versatile steps.
This strategy could nd widespread application by anchoring
Ln(III)-based luminescent probes to diverse biomolecules or
targeting units.20 Photophysical studies demonstrated that this
system allows the sensitization of both NIR-emitting Nd3+ and
Yb3+ ions in aqueous solutions although with moderate effi-
ciency. The analysis of the luminescence lifetimes conrmed
the presence of a water molecule coordinated onto Ln3+ which
causes non-radiative deactivation and partially explains the
relatively modest values of NIR quantum yields. Nevertheless,
the versatility of the described approach that allows: (i) a varia-
tion of substituents on the chromophoric unit in order to
enhance the sensitization efficiency of NIR-emitting Ln3+ ion or
to replace a water molecule from the Ln3+ coordination sphere,
(ii) an exchange of the cyclen coordination unit to the one with
higher denticity, would address current limitations and open
promising possibilities for practical applications of these
molecules.
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Conflicts of interest
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There are no conicts to declare.
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Acknowledgements
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M. C. B. thanks the Association pour la Recherche sur le Cancer
(ARC), the Region Centre-Val de Loire (APR-IR 2011 Multiplex) 11 (a) J. Hedouin, C. Schneider, I. Gillaizeau and C. Hoarau,
and the LABEX SynOrg (ANR-11-LABX-0029) for nancial
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European Community's Seventh Framework Programme (FP7 12 K.-P. Tseng, Y.-T. Tsai, C.-C. Wu, J.-J. Shyue, D. M. Bassani
IEF Dendrimage – project number 316906). S. P. acknowledges
and K.-T. Wong, Chem. Commun., 2013, 49, 11536.
support from the Institut National de la Sante et de la Recherche 13 6 is a well-established cRGD derivative for conjugation with
´
´
Medicale (INSERM). Dr M. Galibert is greatly acknowledged for
imaging probes, see for example: (a) I. Dijkgraaf,
A. Y. Rijnders, A. Soede, A. C. Dechesne, G. Wilma van
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his help with the peptide conjugation reactions. We acknowl-
edge Dr G. Gabant and the mass spectrometry platform of CBM
for the MS analyses of peptides and peptide conjugates.
Notes and references
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M. Schafer, R. Schirrmacher, P. Bartenstein, M. Eisenhut
1750 | RSC Adv., 2019, 9, 1747–1751
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