Phosphorus, Sulfur and Silicon and the Related Elements p. 1269 - 1276 (2003)
Update date:2022-08-04
Topics:
Foroughifar
Mobinikhaledi
Jirandehi, H. Fathinejad
Memar
Pyrimidine derivatives 4a-4c was prepared by a Biginelli cyclocondensation of β-ketoesters, aryl aldehydes, and thiourea derivatives under microwave irradiation. A simple and fast synthesis of bicyclic pyrimidine derivatives 6a-6c was performed by microwave-assisted reaction of 4a-4c with bromomalononitrile (5). Reaction of bicyclic pyrimidines 6a-6c with HCO2H and HONH3Cl under microwave irradiation gave tricyclic pyrimidines 7a-7c and 8a-8c respectively.
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